Sapo Note on Vaso Dilation

Someone was talking on a forum about the need to physically purge when doing sapo/kambo to get the desired effect of a good stomach and liver bile cleansing. To encourage that, a lot of practitioners have their clients drink a couple of liters of water half an hour before a sapo/kambo session. I disagreed. I said that among the indigenous Matses very few people purged and that in my experience forcing the medicine to work on one specific area might be to the detriment of it working on other areas. The example I gave was the clearing of plaque from arteries that would then allow more  oxygen to get to your vital organs, a very beneficial side of the sapo/kambo medicine.
    Someone liked that and asked which peptide in sapo specifically eliminated plaque. This was my response:
George: I'll have to refer to Vittorio Ersparmer's (late, great pharmacologist who worked with the Phyllomedusa bicolor frog that produces sapo/kambo) work to tell you which of the peptides acts as vasodilator. The example I use, and I hope it is a good one, is this: Let's say you are blowing up balloons for your kids and nieces and nephews and letting them fly around the room. Sooner or later one or two will drop behind the couch or what have you and no one retrieves it. A couple of months later someone cleans behind the couch and finds it and your kid asks you to blow it up for him/her again. Only problem is that the balloon is now all scrunched up and non-stretchy because the sugars and proteins in your breath when you were blowing it up previously have all dried and made that balloon no longer stretchable. So you stretch it by hand and those sugars slowly drop off--simply from the act of stretching--into the belly of the balloon and in a few minutes you've got a stretchy balloon again that you can blow up. The plaque in your arteries, or the feathering around your heart valves that can result in an irregular heart beat is a build up of things that eliminate the stretchyness of those arteries, or the smooth opening and closing of those heart valves. Introduce a high powered vaso dilator that blows those arteries open a bit and that plaque will simply fall off into the blood stream and later get eliminated. Same with the feathering of goop that can build up around heart valves. So while Ersparmer did not talk about a peptide that officially eliminated plaque he did talk about the burst of vaso dilation (leading to a temporary drop in blood pressure) that I think would be the equivalent of you stretching out that dried up balloon and causing the sugars to drop off the inside of the elastic skin. Make sense?